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  1. Ilya Lozovsky permalink
    May 26, 2010 7:11 pm

    Fascinating stuff, succinctly explained for the scientifically illiterate. Keep posting more 🙂


    • kevbonham permalink*
      May 26, 2010 8:48 pm

      Hey Ilya, glad you liked it. Tell your friends 😛

  2. Dennis Bonham permalink
    June 2, 2010 4:56 am

    You did a good job in explaining at a level this biology illiterate can understand. When reading the “viruses have viruses” I thought about the book you had long ago that showed a picture of a mite on a flea. I’d like to know more about the difference between a T/B-cell getting stimulated versus receiving a signal. A play by play explanation of a successful detection of a foreign invader by both cell types would be helpful. When you say, “the body assumes”, what part of the body is it?

    • kevbonham permalink*
      June 2, 2010 3:18 pm

      Maybe I’ll write up that play-by-play someday, but it’s pretty complex, and depends a lot on where the infection happens, what type of infection it is, etc. As far as “the body assumes…” basically, I mean the immune system, though giving agency to individual cell types might be a little misleading. There are many levels of regulation and tolerance, one of which is this 2-signal model. T-cells and B-cells require signaling both through their unique receptor (the one that gets made randomly) AND a 2nd signal from an innate immune cell that has seen a pathogen through an innate receptor. In this case, it’s cell intrinsic; if a T-cell sees one signal but not the other, it will turn itself off.


  1. Immune response from start to finish: Part 1 « We Beasties
  2. Immune response from start to finish: Part 2 « We Beasties
  3. Immune response from start to finish: Part 3 « We Beasties

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